MOLECULAR PATHWAYS OF PANNEXIN1-MEDIATED NEUROTOXICITY

Molecular pathways of pannexin1-mediated neurotoxicity

Pannexin1 (Panx1) forms nonselective membrane channels, structurally similar to gap junction hemichannels, that is permeable to ions, nucleotides and other small molecules below 900 Da.Panx1 activity is implicated in paracrine signaling and inflammasome regulation.Recent studies in Extension Wire different animal models showed that Panx1 overactiva

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Experimental intraocular infection of exotic cockerels with field strain of velogenic Newcastle disease virus in Nigeria

Experimental intraocular (conjunctival) infection of exotic Bubble Bath cockerels with a new field strain of viscerotropic velogenic Newcastle Disease Virus (NDV) was conducted to explore the concurrence of some pathological changes with humoral immune responses.After the NDV infection of 4-week-old cockerels, pathologic changes and antibody respon

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